Viagra

What is Viagra? – Explains all the effects / side effects, active ingredients, how to purchase by online, etc.

What is Viagra

” Viagra ” is now widely known as an ED treatment in worldwide .

It was shocking when the drug was first approved in the world.
This is because until then it was recognized that ED ( erectile dysfunction ) was “not cured” or “not ill in the first place”.

However, the percentage of people suffering from ED is very high, and it is said that one in four adult men suffers .

In USA, the Ministry of Health, Labor and Welfare approved it in less than half a year after it was approved by the US FDA (a government agency equivalent to the USA Ministry of Health, Labor and Welfare).

It is said that it usually takes at least 3 to 5 years for a drug approved in the US or EU to be officially approved in Japan, so it can be said that the degree of attention was unusual.

History of ED treatment Viagra

In the first place , “sildenafil”, which is the main component of Viagra , has been under development since the early 1990s as a therapeutic drug for “angina” rather than ED treatment.

However, when clinical trials were conducted to collect clinical data, male subjects reported that “the symptoms of ED had improved” one after another, and clinical trial data as an ED treatment drug was suddenly collected worldwide in 1998. It has a history of being approved in the United States for the first time .

In other words, the therapeutic effect of sildenafil on ED was a kind of “side effect”.
However, there is a considerable causal relationship between ED and angina.
Both are caused by “blood flow disorders”.

Until the world’s first ED treatment drug is made

By the way, the name “Viagra” comes from, but there are various theories about this, but the most prominent one is to combine the medical terms “Vital” and “Niagara Falls” with the image of sperm popping out vigorously. It was named.

Another theory is that the king who built the Taj Mahal in India, which is famous as a World Heritage Site, is unequaled, and is named after the “Agra” where the Taj Mahal was erected.

The world’s first ED treatment drug “Viagra” was launched by Pfizer Pharmaceuticals Headquarters, which has its headquarters in the United States, but research started at a development organization called “Pfizer Sandwich Research and Development” in the United Kingdom.

However, its usefulness for angina, which was the original purpose of development, did not produce good results even after repeated clinical tests.

Given this background, the name “Viagra” may have included the desire to save ED patients around the world and the passion of the researchers involved in the development of this drug. ..

History of Viagra | Pfizer, which developed the ED treatment About Pfizer, which developed the world’s first ED treatment, Viagra. The dream drug Viagra was born from the research of the active ingredient discovered from the treatment of angina. It explains the history of Viagra as to how it was developed and born.

Adaptation to ED treatment and its characteristics

Viagra is the world’s first ED treatment drug, and although several new drugs have been developed since then, it is said to account for 50% of all ED treatment drugs, and it is a drug that is both popular and capable.

ED treatment drug is now known as a drug that improves erectile dysfunction because Viagra has become famous all over the world, but since it was originally developed as a drug for circulatory organs such as angina, it has a high blood flow improvement. It has an effect.

In addition, there are several types of ED in a bite, and it is a characteristic of Viagra that it can be applied (effective) to any of them.

In order to get the full effect of Viagra, it is important to know its characteristics and take it correctly.

The main ingredient of this medicine, “sildenafil”, is fat-soluble.
Therefore, if you take it immediately after eating, it will be bound to the oil contained in the meal and excreted.

In addition, it takes more than 45 minutes after taking the drug until the drug starts to work, and the action time is about 2 to 4 hours.

• Take on an empty stomach
• Drink about an hour before sexual activity

It is generally said that the stomach becomes empty 2 hours after eating.
However, if you eat a fatty meal such as Chinese food or French food, oil may adhere to the gastric mucosa even after 2 hours, and the absorption rate of the medicine may deteriorate.

If you plan to use Viagra after a date, don’t eat too greasy and keep it below the 8th minute of your stomach.
If you take it correctly, there is a nearly 80% chance that it will be effective in erection and maintenance.

The long-awaited erection drug

ED is an acronym for Erectile Dysfunction and is translated as “erectile dysfunction” or “erectile dysfunction” in English.

For ED

• Does not erect during sexual activity (impotence)
• It doesn’t get hard with a half erection
• It withers quickly and does not lead to insertion
• Breaking in the middle (withering during insertion)
• I can’t get along with a specific person (malaise)
• It gets stiff when masturbating, but it doesn’t get stiff during sexual activity
• Unable to maintain an erection without continued strong stimulation

There are various types such as.
Many USA people should have experienced ED symptoms other than complete erectile dysfunction (impotence).

It is said that nearly 30% of adult men have actually experienced the administration of ED treatment drugs.
The number will be even higher if we include potential ED patients (those who are embarrassed and do not go to see the doctor).

Currently, ED remedies can be easily purchased online by using a personal import agency.
It is a “long-awaited erection drug” for those who can have sexual intercourse due to middle folds or half-erections but are suffering from unsatisfactory ejaculation.

Characteristics of Viagra | Effects of therapeutic agents suitable for ED symptoms Let’s understand what kind of ED symptoms Viagra is effective for, its indications and characteristics. Explanation of the reputation of the popular therapeutic drug immediately after its release, the reaction, the reason why it continues to be No. 1 in popularity, and Viagra, which had a great influence on ED treatment.

Viagra developed by Pfizer

From here, I will explain what kind of erectile drug Viagra is.

Viagra was originally developed as a treatment for “ischemic heart disease” called angina, and the main ingredient sildenafil is administered in urgent situations such as pulmonary hypertension (famous for economy syndrome attacks). Made of ingredients.

In other words , you should first know that it is such a strong drug .
And ED remedies are drugs for improving ED , not sexual drugs.

There are also side effects, so I think it is important to deepen your understanding of medicines in order to avoid abuse.

Shape of Viagra

• Diamond-shaped tablet
• Blue color

In USA, sildenafil content of 25mg and 50mg is approved.
For other Viagra groups

• Viagra OP with a pink film that you can drink without water
• Viagra generics such as white and round tablets and blue and round tablets

Is in circulation. Sildenafil content of 50mg is the mainstream for both OP and generics.

The most famous is the blue diamond-shaped “Viagra”, but there are also many inferior counterfeit products on the market.

Viagra and Viagra generics , which are officially approved in USA, are required to be prescribed by a doctor and purchased at a dispensing pharmacy or an in-hospital pharmacy. Never touch the inferior goods sold at sexual activity goods stores.

There are some deaths due to abuse and misuse, so you need to be careful when choosing medicines.

Pharmacology

Now let’s explain how Viagra works on ED.

In the first place, ED is caused by the excessive action of a substance called “PDE5 (phosphodiesterase 5)”, which is an enzyme inside the penis.
In a healthy state, after ejaculation, this enzyme increases inside the penis and suppresses blood flow to the corpus cavernosum tissue.

In addition, PDE5 also has the effect of calming excitement, so when a man finishes ejaculation, the erection ends and sexual desire decreases at once, but for those who have ED, this PDE5 metabolism does not go well and the penis It stays inside and interferes with the erection.

Sildenafil has the effect of inhibiting the action of this enzyme. Viagra’s medicinal properties and pharmacology are to suppress the action of PDE5 in the penis, increase blood flow, and maintain erectile power by taking it just 1 to 2 hours before sexual activity .

Mechanism of Viagra | Mechanism of inhibiting PED5 Sildenafil citrate, the active ingredient of Viagra, is classified as a vasodilator called PDE5 inhibitor and is an ED (erectile dysfunction) treatment drug that has an effect of improving blood circulation. Explains the mechanism such as the shape and pharmacology of Viagra, which is an erection drug.

Active ingredient that Pfizer focused on

Pfizer, which developed and manufactured Viagra, focused on sildenafil’s ability to inhibit PDE5.

Originally, sildenafil was developed to improve blood flow around the heart, but clinical tests reported many secondary effects of inhibiting the action of PDE5 inside the penis, and it was reviewed as an ED treatment drug. It is.

Let’s take a closer look at why blocking the action of PDE5 improves ED.

When a person catches a sexual stimulus from the sense of sight, touch, or smell, the signal is sent to the brain.

The brain converts sexual stimuli into electrical signals and commands the muscle tissue called smooth muscle in the penis to “erection” via the spinal cord.
Upon receiving this command, penile smooth muscle increases the amount of nitric oxide, dilates the penile arteries, and allows a large amount of blood to flow in.

As long as sexual arousal persists, blood flow from the penile arteries to the veins is blocked, and the corpus cavernosum cells (tissue with a sponge-like structure) in the penis swell with blood. This is the mechanism of erection.

However, if this condition continues forever, the penis will become congested, which will slow down metabolism and cause health problems.

Therefore, with ejaculation as a signal, the brain releases PDE5 into the penis to reduce blood flow to smooth muscle and promote blood flow from the penile artery to the penile vein.

Since PDE5 is linked to sedatives in the brain, sexual arousal is also reduced at the same time.

Birth of Viagra | Effect of active ingredient sildenafil Research course until the birth of Viagra. Viagra was originally developed as an ED treatment drug, calling for unexpected discoveries from the development of a treatment drug for angina. It explains the research course and the molecular structure of sildenafil, which is the active ingredient of Viagra.

How to use Viagra

Every drug has side effects, so let’s review the correct use of Viagra once again in this part.

First , take it on an empty stomach 1-2 hours before sexual activity .
When there is no water, it is okay to drink with caffeine-containing tea, coffee or alcohol.

However, it is recommended that you avoid taking it with beverages that contain fat, such as milk.
This is because sildenafil is fat-soluble and dissolves in milk fat, etc., resulting in poor absorption.

The effect of the medicine does not change even if it is chewed and taken, but it is a very bitter medicine, so please take it with water or tea.
When taking with alcohol, do not drink more than the appropriate amount (1 go for sake, 200 ml for wine).

The effect lasts for about 2 to 4 hours, and about 2 hours after taking it is the most effective time zone.

It should be taken once a day, and after taking it, wait at least 24 hours before taking it again .
Even though it is a remedy, it is not necessary to take it continuously. You don’t need to take it if you get enough erections, and you don’t have to take it on non-sexual days.

Viagra is a medicine to maintain erectile power .
Drinking does not increase sexual arousal.

Viagra, which is sold as a sexual drug, is likely to be a non-genuine, inferior product, so please do not touch it.

How to take Viagra | How to take Viagra effectively It is important to take the correct way to get the effect of Viagra. Depending on how you eat and when you take your medicine, you may not be able to get the desired effect. I will explain the correct way to drink Viagra.

Viagra’s active ingredient sildenafil

As explained above, the active ingredient “sildenafil” of Viagra has the effect of inhibiting the action of an enzyme called PDE5 (phosphodiesterase 5).

And since PDE5 is a substance released into the blood by a command from the brain (ejaculation is a signal), sildenafil can be expected to “promote blood flow through the brain”, so now it is not treated for ED. Applied research is also being conducted.

Already used in actual clinical practice are therapeutic agents to control attacks of pulmonary hypertension.
The drug name of the pulmonary antihypertensive drug is “Levathio”.

Sildenafil’s ED , as an application to therapeutic agents other than pulmonary hypertension

• Chronic heart failure
• Ventricular septal defect and patent ductus arteriosus in newborns
• Immune regulation during and after open heart surgery
• Acute lung injury

Etc. are being researched. Although ED is not an immediate life-threatening illness, sildenafil has a very high blood flow-improving effect because pulmonary hypertension and chronic heart failure are life-threatening symptoms when a stroke occurs .

And it is important to take Viagra properly according to the instructions of your doctor or pharmacist.

The ability to inhibit PDE5, the cause of ED

ED is roughly divided into two types, “psychogenic ED” and “organic ED”.
These may occur in a single event, but it is said that they are more likely to merge.

Psychogenic is ED caused by mental factors (stress, fatigue, depression, insomnia, rut, etc.).
On the other hand, the organic one is ED caused by physical abnormalities (hypertension, diabetes, hypotension, etc.).

At around the age of 40, men’s secretion of male hormones decreases, causing symptoms such as menopause in women.
This is called LOH syndrome, but the decrease in sex hormones

• Disturbance of autonomic nerves
• Emotional anxiety
• Decreased libido (psychogenic ED)
• Organic ED

It has been found that the metabolic balance of PDE5 in the body is disturbed.
Laboratory tests have shown that Viagra has a nearly 80% improvement in both psychogenic and organic ED.

Mechanism of action of sildenafil

Until now, we have mainly focused on the action of the enzyme “PDE5 (phosphodiesterase type 5)”, but other substances also affect the onset of ED.

Flow of normal erection mechanism
(1) Receive sexual stimulation mainly centered on vision
(2) The autonomic nerve (central nerve) becomes excited
(3) Excitement is transmitted to the smooth muscle of the penis through the spinal nerves, increasing the concentration of nitric oxide and increasing blood flow throughout the body.
(4) A large amount of amino acid cGMP (cyclic guanosine monophosphate) is produced in penile smooth muscle.
(5) Blood flow in the penile artery rises sharply due to the action of cGMP.
(6) At the same time, the route to the penile vein is closed and the corpus cavernosum tissue is filled with blood.
(7) Ejaculation after sexual activity activates an enzyme called PDE5 to metabolize cGMP.
(8) The erection subsides and blood flow to the veins resumes, resulting in a normal state.

Originally, once PDE5 is metabolized, it is metabolized together with cGMP and is not reuptaked, but when it becomes ED, PDE5 is overactivated and remains in the body even after ejaculation.

Sildenafil (Viagra) has the function of acting on PDE5 and inhibiting its action in order to alleviate this abnormality in PDE5 activation.

Action and effect of Viagra | Effect and characteristics of sildenafil Explain the mechanism of action of sildenafil, the active ingredient of Viagra. What kind of mechanism is improving erectile dysfunction? The onset time and duration of the effect can also be grasped from the absorption and metabolism in the body. Let’s also understand the effects on the diet.

Viagra effect

As already explained, Viagra was first approved as an ED treatment in the United States in 1998.

In the United States, the FDA (Food and Drug Administration), a government agency, collects and approves evidence related to food and medicine.
This standard is a very strict standard even in the world, and clinical tests are conducted every day.

The Ministry of Health, Labor and Welfare of USA will conduct an additional 3 to 5 years of clinical tests to see if drugs approved in Europe and the United States have serious side effects on the constitution and lifestyle of USA people, but Viagra is in the United States. It is a drug that has been speed-approved within a year of its launch in the home country.

In the background, there have been multiple reports of personal imports of inferior products that cause health hazards, but even at the stage of clinical trials in the United States, this drug has an ED improvement effect of nearly 80% and serious side effects. The fact that the data that there were few was released also helped the speed approval.

In other words, Viagra has cleared two extremely strict approval bodies in the world and has been proven to have a high therapeutic effect.

efficacy

The mechanism of action (how the ingredients work, etc.) is explained collectively in the drug’s Noh book and description as “effect / efficacy”, but these two words are essentially similar and different.

• Meaning of efficacy : The function that results from administration
• Meaning of effect : Good results, desirable results, or expectations of administration

In other words, the question of the efficacy of Viagra is “what good results can be achieved by taking Viagra”.

This means that ” the improvement of ED can be expected”.
However, ED is both psychogenic and organic, both of which strongly suspect the presence of underlying illness.

The underlying disorders of psychogenic ED include “LOH syndrome,” “depression,” “insomnia,” “schizophrenia,” “panic disorder,” “fatigue and chronic fatigue,” and “dementia.” Mental illness is possible.

On the other hand, the underlying diseases of organic ED include “lifestyle-related diseases (diabetes and hypertension)”, “sciatic nerve pain”, “ischemic heart diseases such as angina and myocardial infarction”, and “lower limb varices”. Can be done.

effect

On the other hand, the “effect” of Viagra is expected to be “inhibition of PDE5 (phosphodiesterase 5)” and “improvement of blood flow to the penis and circulatory system”.

In addition, although it is still in the research stage, cardiovascular diseases other than pulmonary hypertension (angina, ventricular septal defect), patent ductus arteriosus, thoracotomy and artificial cardiopulmonary It is also expected to have an improving effect on (recovery after surgery, etc.).

Furthermore, it is expected that the improvement of ED will cause mental motivation and improve mental symptoms such as “depression”, “chronic fatigue, and fatigue”.

However, it has been pointed out that when administering to expect such effects, it may be necessary not only to take it before sexual activity like ED treatment, but also to take it continuously, and further clinical test data. Need to be accumulated.

At present, for psychogenic ED, it is recommended to use not only Viagra but also medication treatment (psychotropic drugs and antidepressants) or psychological counseling in psychiatry and psychosomatic medicine.

On the other hand, organic ED has many cases of lifestyle-related diseases as the underlying disease, and since the incidence of ED is particularly high in people with diabetes , treatment of the underlying lifestyle-related disease is given top priority .

Efficacy of Viagra | No. 1 in the name of ED treatment Viagra was marketed by Pfizer in the United States in 1998 as the world’s first ED treatment. Explains the effects of Viagra, which has been extremely popular since its release. The effect will help you understand the secrets of Viagra’s popularity.

How to take Viagra

Drinking Viagra may certainly improve ED .
But that is temporary.
There is also a story that the body becomes resistant to medicines and does not work well when used regularly.

When comparing Viagra with other ED treatments ( Cialis and Levitra ), the order of efficacy and immediate effect is Levidra> Viagra> Cialis.

If you become resistant to Viagra, Cialis may not work, so take measures to improve your lifestyle and take measures against stress so that Viagra will be effective.

Duration of action

Depending on individual differences and the timing of drinking, Viagra has an action time of about 3 hours, and it is about 5 hours at the longest. Clinical data published by Pfizer Pharmaceuticals report that sildenafil, the principal component, was rapidly metabolized after 3 hours in both single-dose and continuous-dose cases.

However, the number of subjects in this clinical test is about 20, and when you look at blogs and reviews on the Internet, you may find that the effect lasted for about 5 hours.

Also, since it is not affected much by alcohol, it is okay to take a glass of wine and 1 cup of sake at the same time, but for people who are vulnerable to alcohol, the blood flow rises sharply, causing a feeling of hotness and red eye. Is more likely to occur.

And Viagra is a medicine that works better on an empty stomach, so be sure to take it on an empty stomach.

The effect starts to appear after about 45 minutes to 1 hour after taking it, but since there are individual differences, I think it is better to try how long it will take for you to get the effect. increase.

How to drink Viagra

It is recommended to take Viagra with water or lukewarm water like other oral medicines.
Although it is less affected by caffeine and alcohol, it is possible that people who are sensitive to these ingredients will have a strong effect of caffeine and alcohol.

However, avoid drinking with milk-fat drinks such as milk and cafe au lait.
Since sildenafil, the main component, is a fat-soluble component, it may be dissolved by milk fat and excreted without being absorbed by the intestines.

100% fruit juices may also contain fatty acids and should be avoided with high-calorie drinks.

Also, avoid greasy meals as much as possible on the day you take it.

It is said that the stomach becomes empty about 2 hours after eating, but people who have had chronic gastritis, reflux esophagitis, gastric resection, or people with gastrointestinal weakness originally have more lipid metabolism than healthy people. It is said that even ordinary people have lipids clinging to the gastric mucosa for about 6 hours.

Why the active ingredient sildenafil is affected by diet

As mentioned earlier, the reason why sildenafil, the active ingredient of Viagra, is affected by diet is “because it has the property of being easily dissolved in oil”, but we also reported data that absorption is faster on an empty stomach. It has been.

A single dose of sildenafil 50 mg to 16 healthy adults in both “postprandial” and “fasting” cases resulted in Tmax (time to reach maximum plasma concentration) “postprandial: 3.0 hours”, “hungry” In the case of hourly administration: 1.2 hours later, the average value was obtained.

Furthermore, the Cmax (maximum plasma concentration) is “14 ng / mL for postprandial administration” and “255 ng / mL for fasting administration”, so if you want to make it work faster and more reliably, you are hungry. There is no doubt that it is effective to drink from time to time.

However, it is actually difficult to take it on an empty stomach because sexual desire tends to decrease when you are hungry, but it is recommended to avoid greasy meals as much as possible and take it about 2 hours after eating. ..

Some doctors say that ED should not be too nervous because it is a test data with a strong psychogenic factor and a small number of subjects.

How to take Viagra | How to take Viagra effectively It is important to take the correct way to get the effect of Viagra. Depending on how you eat and when you take your medicine, you may not be able to get the desired effect. I will explain the correct way to drink Viagra.

Comparison with other ED treatments

In USA, two types of ED treatments are currently approved in addition to Viagra. “Levitra” and “Cialis”.

Levitra is a drug manufactured by Bayer Pharmaceuticals and its main ingredient is “Vardenafil”.
It is a round orange tablet with a vardenafil content of 5 mg, 10 mg and 20 mg, making it the second approved ED treatment in USA.

The characteristics of the medicine are similar to Viagra, but it is said to be a hasty type and the effect of the medicine is stronger than Viagra.
Viagra reaches peaking (most effective) about 2 hours after taking it, while Levitra reaches peaking about 1 hour after taking it.

Side effects such as other characteristics are almost the same as Viagra, but contraindications for concomitant use include some anti-HIV drugs and some antifungal drugs.
It cannot be prescribed to people undergoing hemodialysis.

Cialis is an orange diamond-shaped tablet with 10mg and 20mg, and the main ingredient is “tadalafil”.

The biggest difference from Viagra is that it is “slow-acting and long-acting”.

If you take 20mm , peaking will occur about 3 hours after taking it, and the action will continue for up to 36 hours after that .

It seems that many people feel that the effect is milder and slower than Viagra.
The side effects are mild and the action time is long, so there is an advantage that you do not have to worry about the timing of meals.

It is an ED treatment that is also popular in Europe and the United States. If you take it on Friday night, it works until Sunday morning, so it is sometimes called a weekend pill.

I think that many people think that ED therapeutic agents are Viagra, but Viagra is not the only ED therapeutic agent. Today, not only Viagra but also various ED treatments are on the market, so I would like to introduce them.