Cialis
What is Cialis? -Explains all the effects, side effects, active ingredients, how to purchase by mail order, etc.-
What is Cialis?
ED ( erectile dysfunction ) is a disease that is said to affect one in four adult men.
Many men are worried that they are embarrassed and cannot say it to others, but ED treatments are a strong ally for such people.
Cialis , which boasts the top market share as the third ED treatment , is an ED treatment that lasts for up to 36 hours once taken, unlike conventional Viagra and Levitra .
As a result, you are freed from the pressure of having to have sex on time, which leads to the elimination of impatience and anxiety, and is highly effective in improving psychogenic ED .
Cialis, with its weaker side effects and longer duration, is a great help to men suffering from ED around the world with a different approach than Viagra and Levitra .
History of ED drug Cialis
Cialis , an erectile dysfunction drug, was launched in 2003 by the American company Eli Lilly .
After Viagra and Levitra, it is the third ED treatment developed in the world .
The effects of conventional ED treatments Viagra and Levitra are about 4 to 6 hours, but after taking these drugs, “you have to end sexual activity” and “you have to get angry” before the effect expires. In some cases, such pressures became mentally stressful.
Since many ED patients have ED due to mental stress, it has been pointed out that even though they have a strong effect, they are concerned about their duration, which further exacerbates the symptoms.
Also, if you eat a fatty meal before taking both Viagra and Levitra , the effect will not be sufficient, so you had to be careful about the timing of taking it.
Therefore, Cialis was developed by Eli Lilly and Company to improve these problems.
Once taken , the effect lasts for up to 36 hours , and it is also called the “weekend pill” because of its long-lasting effect.
In addition, it can be used without problems even if you take a meal with a lot of fat, and it has a high degree of freedom due to its low side effects, and it is used all over the world and has the top share rate.
It has been manufactured and sold in usa since 2007, and the number of prescriptions at clinics is very high.
Cialis developed by Eli Lilly
Developed by Eli Lilly and Company , an American pharmaceutical company , Cialis is a breakthrough ED treatment that has the effect of improving erectile dysfunction for up to 36 hours.
In addition , it was manufactured and marketed as an ED drug that is less affected by food and is easy to incorporate into the life cycle without feeling rushed or pressured to have sexual intercourse on time.
Following the conventional Viagra and Levitra, it has been sold in more than 100 countries around the world since it was sold in Europe in 2003 as the world’s third ED treatment drug.
In the first half of 2013, Eli Lilly recorded the world’s largest sales of ED drugs, and now boasts the No. 1 market share in the global market for ED drugs.
Form (tablet)
A third ED drug, Cialis, is an oral tablet-type drug.
It is slightly larger in size than the conventional ED treatments Viagra and Levitra , and has three types of active ingredients, tadalafil, 5 mg, 10 mg, and 20 mg. The shape is dull with an almond-like teardrop shape. It has a yellow color.
Since it is a film-coated tablet, the surface is glossy and the letters “C5” are engraved on 5 mg tablets, “C10” on 10 mg tablets, and “C20” on 20 mg tablets as an “identification code”.
Since Cialis is a popular ED drug, there are many counterfeit products available online.
Unlike the real thing, the color is too bright and the shape is different with black grains mixed in, so be careful when purchasing.
In addition, numbers such as “C50” and “C100” that cannot be genuine are sometimes engraved as identification codes.
Be sure to grasp the real shape firmly and check it if you think it is suspicious.
Medicinal pharmacology
Cialis is a drug for men’s ” erectile dysfunction ” or “erection disorder”.
Its main medicinal effect is to relax the corpus cavernosum smooth muscle in the penis and improve blood flow, leading to a sufficient erection.
Since the effect lasts slowly, it can be classified into psychogenic ED caused by psychological factors, organic ED caused by problems with nerves and blood vessels, or mixed ED combining psychogenic and organic ED . is also known to be effective .
The effect begins about 1 to 3 hours after taking it, and it is effective when sexual stimulation is added.
Cialis is a drug that acts on the penis by increasing blood flow, so taking it does not unconditionally induce an erection or increase libido.
Please note that taking Cialis will not be effective without sexual stimulation.
Pharmacologically, it works by inhibiting the enzyme PDE5 (phosphodiesterase type 5), which calms the erection of the penis.
Called a “PDE5 inhibitor”, it is a drug of the same family as sildenafil contained in Viagra, but tadalafil, the active ingredient of Cialis, has a longer half-life than other drugs and improves erectile function up to 36 hours after taking it. It is characterized by being less affected by the diet when it is seen and taken .
It is popular as an easy-to-use ED drug because the time limit after taking it is lifted and the degree of freedom is high.
Active Ingredients Focused on Eli Lilly
Eli Lilly took over the effects of Viagra, etc., and researched and developed to maintain its efficacy, and was born “Tadalafil”.
When tadalafil is absorbed into the body, it inhibits the action of PDE5 (phosphodiesterase 5), an enzyme that degrades cGMP (cyclic guanosine monophosphate), a substance that promotes smooth muscle relaxation and increased blood flow.
This medicine works on the nerves around the penis to relax the smooth muscles of the corpus cavernosum, dilate blood vessels, increase the blood flow to the corpus cavernosum, and promote erection, leading to the improvement of ED.
The molecular structure of the components of tadalafil is so simple that it has been shown to have long-term medicinal properties. As a result, a long-term effect that
could not be expected with Viagra or Levitra was realized .
In addition, the vasodilating action of tadalafil has been approved as a therapeutic drug for pulmonary arterial hypertension, and it is also covered by health insurance under the name of “Adcirca.”
Furthermore, it is also approved as a therapeutic agent for dysuria caused by enlargement of the prostate associated with benign prostatic hyperplasia and compression of the urethra, and is used not only for ED but also for many other situations.
how to use cialis
When using Cialis, adult males should orally administer 10 mg of Cialis once daily in cold or lukewarm water approximately 1 hour before sexual activity .
Although it is not affected by food, it is said that taking it on an empty stomach has a better absorption rate into the body and has an immediate effect.
If administration of 10 mg is not sufficiently effective, it can be increased to 20 mg if it is judged to be well tolerated and in patients with organic or mixed erectile dysfunction.
However, patients with mild to moderate hepatic impairment should not exceed 10 mg and should be given in one dose per day at intervals of at least 24 hours.
Also, do not take grapefruit juice with it as it can overpower the drug and cause serious side effects .
Store at room temperature, avoiding direct sunlight and moisture.
Cialis has a shelf life of about 2 years.
Don’t forget to ask the hospital about the expiry date if it was prescribed at a hospital.
In addition, if you obtain it by mail order instead of prescription at a hospital, there are cases where the expiration date is approaching, such as within one year.
Please read the contents of the site carefully and check the expiration date.
If the expiration date has passed significantly, not only will it not be effective, but it may also have adverse effects, so be careful when using it.
Cialis active ingredient tadalafil
Tadalafil, the active ingredient in Cialis , is a long-acting PDE5 (phosphodiesterase 5) inhibitor that removes PDE5, an enzyme that interferes with erectile function.
Sildenafil , the active ingredient of Viagra , which is a conventional ED treatment drug , and Vardenafil, the active ingredient of Levitra, have the same effect, but Cialis is a long-acting drug, so erectile function under sexual stimulation lasts for a long time , and oil content is also important. It is a major feature that it is not easily affected by foods with a lot of fat .
It is also used as a therapeutic drug (drug name: Adsilka Zartia) for urinary disorders due to pulmonary arterial hypertension and benign prostatic hyperplasia as well as ED ( erectile dysfunction ) by utilizing the vasodilatory effect of Cialis .
The ability to inhibit RDF5, the cause of ED
An erection in a man is caused by a process in which the brain senses sexual stimuli and signals are transmitted to the penis through nerves, the smooth muscles of the penis relax, and blood flows into the corpus cavernosum.
At this time, when a signal is transmitted to the penis, a substance called cGMP (cyclic guanosine monophosphate) increases, the smooth muscle of the penis relaxes, and the blood vessels dilate.
An enzyme called PDE5 removes cGMP, which is very important for erections.
Tadalafil, the active ingredient in Cialis, blocks PDE5 and increases cGMP in the penis, which is why Cialis is also called a PDE5 inhibitor.
Similarly, other ED treatments such as Viagra and Levitra have the same effect and are PDE inhibitors that prevent the destruction of cGMP.
Tadalafil is not an aphrodisiac or a drug that promotes libido, so even if you take it, it will not be effective unless you give it sexual stimulation.
Utilizing this effect, it is also active as a therapeutic drug other than ED , such as being used as a therapeutic drug for dysuria due to benign prostatic hyperplasia, and further research and development is being promoted as a safe ingredient with few side effects if used properly. I have.
Mechanism of action of tadalafil
The active ingredient, tadalafil, inhibits the activity of PDE5, an enzyme that decomposes cGMP, which promotes an erection.
When a man feels sexual stimulation, a command from the excited cerebrum is transmitted to the erectile center via the spinal cord, nitric oxide is secreted from the arteriole wall of the penis, and cGMP, a vasodilator, increases.
The mechanism of erection is that the blood vessels around the penis expand due to the action of cGMP, blood flow increases, blood flows into the corpus cavernosum, and the penis expands.
The penis returns to normal when libido subsides or after ejaculation the secretion of an enzyme called PDE5 that suppresses cGMP and calms the erection.
However, ED is a symptom that PDE5 is excessively secreted for some reason, and even if it erects, it quickly withers or the erection itself becomes impossible, and it becomes impossible to perform satisfactory sexual activity.
In the case of ED caused by PDE5, the active ingredient, long-acting tadalafil, suppresses the action of the PDE5 enzyme, so it is possible to support sufficient erection and its continuation.
Other indications for tadalafil
Cialis is often used in addition to the treatment for ED, and is mainly prescribed for “pulmonary arterial hypertension” and “dysuria associated with benign prostatic hyperplasia”.
“Pulmonary arterial hypertension,” which is said to affect about 6,000 people in usa, causes an abnormal increase in pressure in the blood vessels (pulmonary arteries) that send blood from the heart to the lungs, placing a heavy burden on the heart. It is a disease that makes it difficult to supply oxygen to the whole body.
This disease is also certified as a designated intractable disease, and it requires treatment to expand blood vessels in the lungs and improve blood flow.
PDE5, an enzyme that inhibits vasodilation, is abundant not only in the corpus cavernosum of the penis but also in the smooth muscle of the pulmonary artery. It has the effect of suppressing and lowering pulmonary arterial pressure and pulmonary vascular resistance.
For the treatment of pulmonary arterial hypertension, it is prescribed under the drug name “Adcirca”, and unlike ED treatment, which is considered a private practice, it is covered by health insurance.
In addition, PDE5 is also abundant in the smooth muscles of the prostate and urethra, and taking tadalafil inhibits PDE5, suppresses the decomposition of cGMP, dilates constricted blood vessels, loosens the compressed urethra, and improves symptoms. It is also used to do.
The prostate gland is an organ just below the bladder that surrounds the urethra.
Therefore, when the prostate enlarges, the urethra is compressed, making it difficult for urine to come out and leading to urinary disorders such as a feeling of residual urine.
Cialis is prescribed under the name “Zartia” in the treatment of dysuria due to benign prostatic hyperplasia, which is also covered by health insurance.
Cialis effect
The third ED treatment, Cialis , is a highly flexible treatment that retains the advantages of conventional ED ( erectile dysfunction ) treatments such as Viagra and Levitra, but with the disadvantages improved by Eli Lilly .
It has become easier to incorporate into daily life, such as a long-lasting effect that could not be achieved with previous ED drugs and the removal of restrictions on high-calorie meals, and it has become possible to save a wider range of patients suffering from ED. .
Today, Cialis is used in more than 100 countries around the world and supports many men.
Once taken, the effect lasts for nearly two days, so we will explain in detail the detailed effects and effects of Cialis, which boasts the largest market share in the world.
efficacy
Cialis is an ED drug taken for the purpose of improving ED.
It is the same PDE5 inhibitor as Viagra and Levitra, which are other ED drugs, and its effects are almost the same.
In order for the male genitalia to erect, the blood vessels in the penis must be dilated by the action of a component called cGMP (cyclic guanosine monophosphate).
As a result, a large amount of blood flows, and the male genitalia are designed to erect normally.
However, since the enzyme PDE5 (phosphodiesterase 5) has a function of destroying cGMP, if PDE5 is not secreted at an appropriate timing and is excessively produced, blood vessels will not be dilated and sufficient erection will not be possible, which will be a major factor in ED. increase.
PDE5 inhibitors such as Cialis are drugs that block the action of PDE5 and have the effect of causing vasodilation and leading to normal erection.
effect
Cialis, an ED drug, has been shown to promote normal erection when sexual stimulation is applied for 20 to 24 hours at 10 mg and 30 to 36 hours at 20 mg after administration.
Unlike Viagra and Levitra , it is less susceptible to oily diets.
Therefore, it is possible to greatly reduce the anxiety of having to end sexual activity before the timing of administration and the drug effect expires, and psychogenic ED caused by mental stress or a mixture of psychogenic and organic. It is also said to be effective for sex ED .
In addition, the incidence of side effects such as hot flashes and red eye is lower than Viagra Levitra.
Also, like other PDE inhibitors, Cialis does not have the aphrodisiac effect of boosting energy, promoting sexual arousal, or forcing an erection.
After ejaculation, the erection will subside if the sexual excitement subsides with the medicine that will help you get an erection when you get sexually stimulated, so you don’t have to worry about it interfering with your daily life.
However, if it is within the action time, the effect will be manifested when you get an erection due to sexual excitement, so it is very popular with people who want to enjoy sexual activity many times over a long period of time.
Effects of Cialis based on clinical data
As a clinical trial of Cialis in USA, 343 ED (erectile dysfunction) patients were divided into a placebo group, a Cialis tablet 5 mg group, a 10 mg group, and a 20 mg group, and a survey was conducted on efficacy and safety. was.
The effectiveness of the study was assessed by the erectile function domain score in the International Index of Erectile Function (IIEF), and by the questionnaire on sexual intercourse in the diary that the patient wrote during the trial (Sexual Encounter Profile (SEP)). Percentage of respondents who answered “yes” to question 2 “Were you able to insert your partner’s vagina?” was judged on the basis of
As a result, effective improvement was observed in all endpoints at all doses of Cialis 5mg, 10mg, and 20mg, proving the efficacy of Cialis for usa ED patients.
Analysis of patients with severe ED showed a dose-dependent improvement in the IIEF and SEP questions of IIEF and SEP, with the greatest improvement observed in the 20 mg group. is.
In clinical trials conducted in usa, the major side effects observed in 257 patients who received Cialis were headache in 29 cases (11.3%), hot flashes in 22 cases (8.6%), and dyspepsia in 6 cases (2.3%). However, the majority of them have mild to moderate symptoms and no serious side effects have been reported.
Based on this report, Cialis is recognized as an effective treatment for ED with few side effects.
How to take Cialis
Cialis , which is said to have few side effects among pharmaceuticals, is a reliable drug that has a tremendous effect on ED ( erectile dysfunction ) and restores confidence in men if used correctly and appropriately . It should be taken in a timely and manner.
There are three types of Cialis tablets: 5mg, 10mg, and 20mg .
Avoid changing the usage or dosage based on your own judgment in order to obtain a better effect, as this may lead to serious side effects.
In order to use Cialis safely, this item explains in detail the correct dosage method, action time, precautions, etc.
Duration of action
Cialis differs greatly from Viagra and Levitra in its “duration of action”.
Although it lacks immediate effect, it has the great advantage of lasting up to 36 hours of action compared to conventional ED drugs .
In overseas experiments, 2,012 patients with erectile dysfunction were orally administered 20 mg of Cialis once a day for 12 weeks at the required time, and it was effective for up to one and a half days, resulting in satisfactory sexual activity. The results show that the percentage of people who were sent exceeded 70% .
In addition to the long duration, it works slowly and has weak side effects, so it is suitable for psychogenic ED, which has not been very effective with conventional ED treatments, and mixed psychogenic and organic ED. Is also valid .
If taken on Friday night, the effect lasts until Sunday morning, so it is called “weekend pill” overseas, and it quickly overtook Viagra and jumped to the top of the market share.
Viagra’s market share is still high in usa, but the number of men using Cialis is gradually increasing.
how to take cialis
Do it once a day, and be sure to wait 24 hours before taking the next dose .
When taking this medicine, keep oral administration with water or lukewarm water.
It is said that food has no effect, but it is said that the absorption rate is better and the effect is more likely to be obtained when taken on an empty stomach rather than after meals .
Tadalafil, the main ingredient of Cialis, is a white powder that is insoluble in water.
Therefore, the effect of Cialis is not as immediate as Viagra or Levitra , and the time to reach the maximum blood concentration after taking it is 30 minutes to 4 hours, which varies from person to person.
As a rough timing, it is considered appropriate to take it 3 hours before sexual activity .
Cialis is said to be less affected by alcohol than other therapeutic drugs, but since it has the effect of dilating blood vessels, taking it with alcohol improves blood flow and alcohol circulation. There is also the possibility of getting sick.
Excessive alcohol intake can also reduce erectile function, so be careful when using ED medications.
It is said that if the amount is moderate, it will have a relaxing effect and synergistic effect with the effect of Cialis will improve erection more effectively.
Dietary Effects of Active Ingredient Tadalafil
One of the features of Cialis is that it is less affected by food.
This was a big improvement compared to Viagra and Levitra that had been released until then.
Viagra and Levitra, which are known for their powerful effects, have problems such as diminishing effects after a fatty diet, so you must be careful about your diet.
Regarding Cialis, at the time of its release, the manufacturer Eli Lilly’s material stated that “a meal up to 800 kcal has no effect.”
This notation seems to have disappeared now, but this 800kcal is about the same amount of calories as one plate of pork curry, and it is said that a normal meal will not exceed this calorie.
However, it has been reported that the effect of Cialis decreases after eating a diet high in oil and calories, so when taking it, do you eat a light meal such as usa food instead of a diet high in fat? , Take 2 hours after meals .
It is a fact that Cialis, like Viagra and Levitra, has a better absorption rate into the body and has an immediate effect when taken on an empty stomach.
If you want to feel the effect, we recommend taking it on an empty stomach.
On the other hand, it is true that Cialis has significantly fewer dietary restrictions than other ED drugs, so it is important not to get nervous.
Comparison with other ED drugs
The characteristics of ED treatments used in the world differ depending on each tablet, and it can be seen that Cialis is significantly different from conventional ED treatments.
First of all, Viagra is the world’s first ED treatment drug that begins to feel the effect about 30 minutes to 1 hour after taking it and has a duration of effect about 3 to 4 hours after taking it.
Compared to the other two drugs, Viagra is characterized by its strong effects in a short period of time .
However, it has the disadvantage that it is difficult to obtain the effect after a meal with a lot of oil, and there is also a restriction that you must wait one hour before taking it after a meal.
A major feature of Levitra, the second ED drug, is its immediate effect .
The effect starts to appear about 30 minutes after taking it, but it appears so quickly that some people report that it takes about 10 minutes.
The duration of the effect is about 5 to 8 hours, which is a little longer than Viagra.
It tends to be less affected by diet, but it should be noted that a greasy diet may weaken the effect.
Cialis, which was developed following the above-mentioned ED treatment drug, is characterized by its erectile dysfunction-promoting effect lasting for about 30 to 36 hours compared to others .
You don’t have to worry about the timing of taking it, you don’t feel the pressure of having to finish sexual activity in time, you can use it according to your lifestyle, and it is not affected by meals, so it is the only one that you can take before meals. It is a drug and is popular as a remedy with a high degree of freedom even after taking it.
cialis side effects
When used properly, ED treatments can be safely and highly effective and can effectively improve ED ( erectile dysfunction ).
Cialis is said to have relatively few side effects among ED treatments , but it is also true that some side effects have been reported due to the vasodilatory effect of taking it.
Most of them have mild symptoms such as migraine, dizziness, and myalgia, which heal spontaneously over time, but serious side effects such as rare facial edema and sudden hypotension have also been reported.
If the side effects persist for a long time, stop taking them immediately and consult your doctor.
Main side effects
Tadalafil, the active ingredient of Cialis, inhibits PDE5 (phosphodiesterase 5), which interferes with erectile function, and increases cGMP (cyclic guanosine monophosphate) in the penis to increase blood flow and achieve a sufficient erection.
On the other hand, some mild side effects have also been observed due to its vasodilatory effect and increased blood flow.
Most of the side effects after taking Cialis are mild symptoms such as “dizziness”, “hot flashes”, “migraine/headache”, but there are also “dyspepsia”, “malaise”, “palpitations”, and “muscles”. side effects such as pain.
Even if these side effects occur, there is no problem if the symptoms subside within a few hours, but if the symptoms do not subside for a long time, stop taking this medicine and be sure to consult a doctor.
If left unattended, it can also cause serious health hazards.
Erection lasting more than 4 hours after taking Cialis can also be dangerous to erectile function if proper measures are not taken.
If so, please seek medical attention immediately.
Symptoms such as dizziness and lightheadedness may occur after taking Cialis, so avoid working at heights or driving a car after taking this medicine.
Rare side effects
Cialis is known to have relatively few side effects among ED drugs .
However, according to clinical trials of Cialis, mild side effects occurred in 30% of all patients, and severe symptoms occurred in a very small number of cases.
The incidence of serious conditions is as low as less than 0.2%, so there is no need to worry too much about it, but keep in mind that there is such a possibility when using Cialis. .
Most of the symptoms of serious side effects are hypersensitivity (rash, urticaria, facial edema, exfoliative dermatitis, Stevens-Johnson syndrome). Other serious side effects include “chest pain,” “tachycardia,” “hypertension,” “hypotension,” “renal dysfunction,” “dyspnea,” and “erection enhancement.”
The side effects can be very dangerous, especially for people with heart disease.
There have been no serious reports of these hypersensitivities in usa yet, only overseas, but you never know when and who will get side effects.
If you experience any of these symptoms, discontinue use immediately and, if prescribed, have the clinic or other medical institution take appropriate measures.
Precautions when using Cialis
Cialis is a highly effective and safe drug when used properly, but like other ED drugs such as Viagra and Levitra , there are precautions to be taken when using it.
Even Cialis, which is said to have weak side effects, is, as the name suggests, a drug for ED treatment .
Improper use of this product can have adverse effects on your health, so be sure to read the precautions carefully before using it.
Also, Cialis is not a drug that everyone can take.
Some people should not take it. If you are taking any medications or have any medical conditions, please discuss them with your doctor.
Below is a detailed explanation of precautions when taking Cialis and examples of when you should not take Cialis, so please refer to it when purchasing.
people who take caution when taking
Do not take Cialis if you have had any allergic symptoms, such as itching or rash, due to previous use of medicines.
Also, those who have cardiovascular disorders, unstable angina, arrhythmia, hypotension, hypertension, liver disorders, retinal pigment degeneration, those who have angina during sexual intercourse, myocardial infarction within the last 3 months If you have an infarction or have had a cerebral infarction or cerebral bleeding within the last 6 months, you should not take Cialis.
In addition, you should be aware of any medications you use regularly , as there is a risk of over-action due to drug interactions .
In particular, alpha blockers, antihypertensive drugs, and drugs for acute heart failure, which are some of the drugs for hypertension and prostatic hypertrophy, are also certified as concomitant medications, so stop taking them or consult your doctor. Please be so.
These contraindicated drugs for concomitant use include all drugs containing the ingredients, regardless of whether they are oral drugs, topical drugs, prescription drugs, or over-the-counter drugs.
If you are taking a variety of medicines on a regular basis, or if you are using any of the above-mentioned medicines, it is better to prescribe Cialis at a clinic in usa under a doctor’s diagnosis than to purchase it on your own. It’s safer to get
If you take it on your own judgment, it may cause serious side effects or even death, so be careful.
Caution for combined use
Unlike contraindicated drugs, concomitant medications can be used in combination with ED treatments if you are careful about their precautions.
The first is an antiarrhythmic drug. In Viagra , some antiarrhythmic drugs are contraindicated in combination, but Cialis is “cautionary in combination”, but the combined use may cause abnormal heartbeat and improve health. Be careful as it is said to be harmful .
In addition, tadalafil has a vasodilatory effect and has the effect of lowering blood pressure, so when used in combination with antihypertensive drugs, blood pressure may drop too much.
Among antihypertensive drugs, alpha blockers have been reported to cause a significant decrease in blood pressure that causes fainting.
Concomitant use with potent CYP3A4 inhibitors such as ketoconazole may interfere with the normal metabolism of tadalafil, as studies have reported elevated plasma levels.
Oral antifungal drugs, which are often prescribed for deep-seated mycosis (tinea unguium), etc., are said to increase the blood concentration of ED treatment drugs when used in combination with Viagra and Cialis. Therefore, caution should be exercised when using both together. There is no problem as long as the antifungal drug is applied as an ointment.
Caution should be exercised when using antiviral drugs, especially drugs for treating HIV (AIDS virus).
Interactions can increase blood levels of drugs used to treat ED .
Some doctors prohibit the combined use of HIV treatment drugs, so be sure to consult with your doctor.
Persons who should not take
Cialis is a relatively flexible and easy-to-use drug among ED drugs, but some people should not take it.
Those with cardiovascular disorders who are prohibited from sexual activity, those who have had sexual activity in the past, those who had an attack of angina pectoris, those who had a history of myocardial infarction in the past 3 months, This applies to heart disease patients such as those with unstable angina pectoris, those with hypotension who are not receiving appropriate treatment at a hospital, those with arrhythmia, and those taking nitrates for this purpose. .
In addition, people with a history of cerebral infarction or cerebral hemorrhage in the past 6 months, people with severe hepatic dysfunction, and people taking HIV treatments are also seriously injured by the combined use. It is said that this may occur and it is prohibited to take it.
Due to its nature, ED treatments such as Cialis cannot be taken by people who have heart disease or liver problems.
There is a risk of death if you use it on your own to get the effect of improving erectile dysfunction, so if you are thinking about using it, please consult with your doctor in advance.
Contraindicated drug
Cialis, an ED treatment drug, is not suitable for everyone, and there are contraindicated drugs that are difficult to swallow and are prohibited from being used in combination.
Nitrate agents such as nitroglycerin, which are often used for heart disease such as angina pectoris, can cause a sudden drop in blood pressure and cause serious side effects.
Concomitant use can be life-threatening, so those who are receiving nitrate treatment for heart disease should never take Cialis together.
In addition to oral medicines, nitrates include sublingual medicines, patches, inhalants, injections, ointments, and sprays.
If you do not know whether the medicine you are using is applicable to nitrates, please consult your doctor without self-judgment.
If you are taking nitrates, be aware that you will not be able to prescribe ED medications at hospitals or clinics.
Cialis is also incompatible with HIV drugs and cannot be used in combination.
Since HIV drugs significantly inhibit the action of liver enzymes, there is a risk that the drug concentration in the body will become too high if used in combination with the ED drug Cialis.
Concomitant use of amiodarone-containing drugs, which are used for ventricular fibrillation and heart failure, may cause fatal arrhythmia.
Cialis generics
Cialis , a popular treatment for ED all over the world , basically has no generic drug in any country because Eli Lilly’s international patent has not expired .
Of course, there is no distribution of generic Cialis in usa, and it is not possible to get prescriptions at clinics.
However, there are already many types of Cialis generics in India, and it is possible to purchase them by personal import from overseas mail order.
So why is there a generic version of Cialis in India?
And are Indian generics safe?
In this section, we will explain the detailed reasons and the types and shapes of Cialis generics that you are interested in.
Cialis generic development
Regarding the manufacture of Cialis generics, the “substance patent” of tadalafil, which is the active ingredient of Cialis owned by Eli Lilly and Company, and the “use patent” for the treatment of erectile dysfunction have been developed until the patent period expires or becomes invalid. It is a rule that you cannot do it.
Cialis is not allowed to make Cialis generics as international patents have not yet expired.
However, Indian patent law did not allow “substance patents” until the patent law was amended in 2005.
As a result, generic drugs of various drugs for which international patents are still valid could be manufactured in India.
Although substance patents were introduced in 2005, generic drugs prior to January 2005 are still available for sale .
Cialis, which was sold in the United States in 2003, is also manufactured in India as a generic and can be imported by mail order overseas.
Therefore, Cialis generic drugs are only available in India.
We will introduce the types below, but there are many counterfeit products from overseas products imported by individuals, so be careful when obtaining them.
Various types
There are different types of generic Cialis manufactured in India and they come in different shapes .
In particular, generic drugs sold by major Indian pharmaceutical companies are popular overseas and are used by many people.
Tadalis, which is manufactured and sold by Ajanta Pharma, a major pharmaceutical company that is also famous for manufacturing and selling Viagra generic Kamagra, is officially called Tadalis SX , and is a popular product among Viagra generics.
The active ingredient is tadalafil, the same as Cialis, and comes in 10mg and 20mg tablets. In addition, generic drug Tadacip manufactured and sold by Cipla
, a major pharmaceutical company based in Mumbai, and Tadalift manufactured and sold by major Indian pharmaceutical company Pfizer , which is famous for manufacturing Viagra, are also sold in India 1 It is manufactured and sold by many pharmaceutical companies, such as Forzest , which is manufactured and marketed by Sun Pharma , the world ‘s largest pharmaceutical company .
The active ingredient is tadalafil, which is the same as Cialis, so you can buy it cheaply while having exactly the same effect as Cialis.
However, unlike the genuine product, the shape varies depending on the pharmaceutical company, so it is difficult to distinguish the placebo.
Please be careful when purchasing.
shape type
The official Cialis product is only oral tablet type, but generic drugs are sold in various forms such as tablet type, sublingual tablet type, troche and jelly type.
Among the generic drugs released by Ajanta Pharma , Tadaris is a pale yellow elongated oval tablet sold in 10 mg and 20 mg.
20mg is sold for about 300 yen and looks similar to the original Cialis, but it has a slightly different shape and is not marked with “C10”.
As you can see, many of the tablet-type generic drugs look a little different from the official Cialis, so keep that in mind.
As another ED treatment drug sold by the same company, Apkaris SX Oral Jelly is a jelly-type treatment drug with 7 types of flavors such as orange and strawberry flavors, and 20 mg per bag is sold for about 400 yen.
Tadalista Pro CT 20mg, sold by Indian generic manufacturer Fortune Healthcare , is a sublingual tablet that can be taken without water .
However, 10mg and 20mg of all of them are considered to be legitimate medicines, and 50mg and 100mg are not sold and are counterfeits, so be careful when purchasing.
What is “Megalis” famous for Cialis generic?
Megaris , a generic product of Cialis, which is also popular in overseas mail order, is manufactured and sold by Indian pharmaceutical company McLeods , which is growing rapidly even in India.
The shape of the Megalis tablet is an orange-pink round shape, which is very different from the original Cialis, and the tablets are individually wrapped.
There are two types of content, 10mg and 20mg, just like Cialis.
Cialis 20mg is sold at a price of about 2,000 yen per tablet, while Megalis 20mg is sold at a price of 500-700 yen per tablet .
However, Megalith is not officially licensed outside of India and is made under India’s special patent laws.
Since it is a major pharmaceutical company, there is no problem with the ingredients, but there is no legitimate route to enter usa.
Therefore, the only way for us usa to buy is to go to India and buy directly or rely on private imports from overseas.
Because it is a popular item, there are many counterfeit items on the market, so be careful when purchasing.
Benefits of Cialis Generic
A third ED drug, Cialis, is a slightly more expensive pill than other ED drugs, Viagra and Levitra .
Viagra is manufactured and sold as a regular generic drug, and it seems that Cialis feels even more expensive because it can be purchased at a lower price.
However, generic Cialis has the advantage of being much cheaper than the original product and easier to use continuously.
In the case of Cialis tablets, Eli Lilly’s international patent has not expired yet, but the patent law in India applies only to the pharmaceutical process, making it possible to manufacture generic drugs.
Strictly speaking, the medicines manufactured by Indian pharmaceutical companies cannot be said to be generic drugs from an international perspective due to the patent period. are considered generic drugs.
It seems that there is a big merit in terms of money because it can be obtained in the form of personal import even in overseas mail order etc.
However, it is necessary to be very careful when purchasing, as many of the products sold at extremely low prices are counterfeit products.
Beware of fake cialis
Nowadays, overseas mail order via the Internet has become mainstream, and ED medicines such as Cialis can be easily obtained online using mail order by personal import agency sites .
As a result, many counterfeit ED treatments have become available, and the surprising result is that 55.4% of the ED treatments sold online in usa are counterfeit.
In particular, Cialis has more counterfeit products than Viagra , and it is said that 60% are counterfeit products, and they are sold under the guise of genuine Cialis and generic Cialis .
The following is a detailed explanation of the actual accidents caused by counterfeit Cialis products and the import of personal oil from overseas pharmaceutical products, so if you are considering purchasing it, please keep this in mind.
Cialis domestic prescription
Cialis was developed by Eli Lilly in the United States as the world’s third ED ( erectile dysfunction ) treatment , and was launched in usa in 2007.
It can be prescribed at clinics that handle ED treatment in usa, and it can be said that it is the safest way to obtain it because you can get a prescription for a genuine product.
However, prescriptions for Cialis are not covered by health insurance, so you will have to pay for the treatment at your own expense.
Since it is completely self-pay medical treatment, information will not be leaked and will not be recorded in the history of the insurance card, so you can have a medical examination with peace of mind.
Most ED specialist clinics in usa are men-only clinics where all the staff are men, so it is easy to visit.
The contents of the examination are simple, such as blood pressure measurement, and there is no actual palpation or showing the genitals.
If you have a prescription at a hospital, you can have a thorough interview with a specialist doctor, so you can understand your ED condition and receive appropriate advice and the amount of Cialis prescribed.
It’s much safer and more correct to take than buying online without a medical examination, so if you’re thinking of taking Cialis, you should first rely on domestic prescriptions to find out if it suits you. I recommend it.
Private import of overseas pharmaceuticals
When importing from overseas for personal use, it is basically necessary to obtain permission from the Ministry of Health, Labor and Welfare, but if it is within the fixed range, it will be possible to import after receiving confirmation from customs.
Cialis is a drug, and if it is a prescription drug, it can be imported in an amount within one month.
However, the disadvantage is that personal imports are difficult because they are directly exchanged with foreign countries.
Therefore, the “Personal Import Agency Site” will act as an agent for personal imports.
Since the agency site will handle everything from difficult procedures to shipping, you can purchase products as easily as mail order.
Personal import has the advantage that you can easily get the medicine you want, but since you will buy it only with your own knowledge, you may take it incorrectly if you do not have the correct knowledge.
Even if there are side effects or harmful symptoms, it will be a disadvantage that you will be responsible for all of them, so it is important to have a solid knowledge, such as consulting a doctor in advance.
It usually takes more than 7 days to get imported medicines.
In rare cases, some agents stock products and ship them immediately, but this is an illegal act, so be careful of drug sites that claim to ship on the same day.
About counterfeit products
Among the ED treatments, Cialis has many counterfeit products on the market, and it contains more active ingredients than the approved amount, does not contain any active ingredients, or is a harmful ingredient that is not contained in genuine products. May be included.
Genuine Cialis has a specific shape and markings, and anything else is counterfeit.
If in doubt, be sure to check it out.
Cialis tablets have an almond-like seed-like shape and a dull yellow color.
The content of the genuine product is 5mg, 10mg, and 20mg. They are engraved with “C5”, “C10”, “C20” depending on the content.
It has been reported that many counterfeit products have different markings, such as “C50” or “C100”.
Some unscrupulous online shopping sites claim that the product contains more tadalafil than the genuine product, but it is 100% counterfeit, so please do not get involved.
Counterfeit products also vary greatly in price.
Genuine Cialis costs about 500 yen per tablet, but counterfeit products are often cheap, and most of the counterfeit products are sold at exceptional prices, such as 4,000 yen for 10 tablets.
Accident caused by counterfeit product
Genuine Cialis is known to have few side effects, but counterfeit ED treatments such as Cialis currently available online can have serious side effects and can be harmful to your health.
In 2008, the worst accident occurred in Singapore, where four people died and seven people were brain-dead after taking a fake Cialis.
Later research revealed that Cialis contained more than four times the daily intake limit, which became a hot topic.
Another case in usa was that the ED treatment drug purchased online contained rodenticides and narcotics, and the man who used it became unconscious and was urgently transported.
ED (erectile dysfunction) is also a problem that is difficult to consult with people, and many people try to solve it by themselves.
For this reason, there are many people who unknowingly go out of their way to counterfeit mail-order products.
Even after taking it, they hide the fact that they have taken counterfeit ED drugs out of shame, and when symptoms appear, they may not be able to take appropriate measures.
It is important to consult with a hospital first and face the disease of ED before it causes serious damage to your health .
Also, when importing by mail order for personal use, be sure to understand that you need to make a careful decision before purchasing.
how to buy cialis
There are two ways to purchase Cialis : get a prescription from a clinic in usa or import it personally from an overseas mail order.
It can be said that the method of getting a prescription at the first domestic clinic is the safest method because you can get a proper amount of prescription by consulting with a doctor and get a prescription of a genuine product.
The second is personal imports through overseas mail order, which can be easily obtained by yourself without the hassle and embarrassment of going to the hospital . There is also the risk of getting counterfeit medicines that cause
The two methods are explained in detail below, so please refer to them.
Cialis domestic prescription is free medical treatment
Cialis is said to be a drug not listed in the NHI price standard and is classified as a drug not covered by insurance.
Therefore, it is important to understand that Cialis prescriptions are “own expense” at any medical institution or clinic.
There are three types of Cialis currently prescribed by medical institutions in usa: 5 mg, 10 mg, and 20 mg. Please note that
50mg and 100mg do not exist in domestic genuine Cialis .
In free medical care at a medical institution, the initial consultation fee, examination fee, medicine fee and prescription fee will be charged. Depending on the clinic, there are places where the initial consultation fee and consultation fee are free, so it is a good idea to choose a place that is convenient for you.
The initial consultation fee and consultation fee are about 5,000 yen, and the drug fee for Cialis is about 1,600 yen per 10mg tablet.
If you add various other tests, the test fee will be added here.
Also, if Cialis is cheaper than the normal price or if you are told about Cialis generic , it may be counterfeit. Currently, no generic drug
for Cialis is approved in usa.
Recently, it has been reported that there are medical institutions that prescribe cheap non-genuine Cialis purchased by private import, so be careful where the conditions are too good.
Not available at pharmacies and drug stores
Since ED treatments are medicines, can’t they be purchased at pharmacies or drug stores? There are two types of drugs currently being handled in usa, “prescription drugs” and “over-the-counter drugs”.
Over-the-counter drugs are called “over-the-counter drugs” and can be sold at pharmacists and drug stores, and anyone can purchase them without consulting a doctor or prescribing.
However, Cialis, which is an ED treatment drug, is called a “prescription drug” and is a “medical drug”, so it is highly effective and there are concerns about side effects in some cases. you can’t.
Therefore, not only Cialis, but also other ED drugs such as Viagra and Levitra cannot be purchased at pharmacies and drug stores.
There are only two purchase methods: “Prescribe at a clinic that handles ED treatment in usa” or “Overseas mail order by personal import”.
In the case of domestic prescription, only genuine products are available, but you can also purchase generic drugs made in India through overseas mail order .
If you are sold at a pharmacy or other store in usa claiming to be an ED remedy, or if someone else offers to sell it to you, it is most likely a counterfeit product, so please do not buy it.
Cialis mail order situation
Among the ED drugs, Cialis, which can be used stably, is very popular and is a popular product even in overseas mail order.
In particular, generic Cialis drugs have not yet been approved in the world, so some clinics cannot prescribe them.
Although it is a generic drug made under India’s special patent law, it seems that many people trust and purchase it because there is no problem with the ingredients because there are achievements so far in major pharmaceutical companies.
However, due to its popularity, the number of malicious overseas mail-order sites has increased, and it is also true that there are many counterfeit products on the market.
Most people try to purchase generic drugs online, but it is difficult to distinguish between counterfeit and counterfeit generic drugs because many of them are different in shape from genuine products.
There have been fatal accidents overseas, so you need to be careful.
Especially for personal import, only 20mg tablets of Cialis are handled.
There is a product called 100mg, but don’t be fooled as it is not in the official standard.
Most of them are genuine products, and the market price is that one Cialis 20mg tablet is sold for about 1,600 yen.
It is said that products that are said to be genuine but are significantly cheaper than this price are often counterfeit products, so be careful.
There is no problem with individual imports of medicines as much as the fixed number (quantity) is purchased by the person himself / herself , but even if he / she keeps it, there are many people who buy overseas medicines individually and get a fake.
If you use a fake that contains toxic substances, it can be life-threatening, so one way to use Cialis safely is to purchase it online at a reliable personal import agency site.
Summary of Cialis
The third ED drug, Cialis , lasts for up to 36 hours once taken, and is not easily affected by oily meals, so there is no need to worry about when to take it. I am proud of the top and give confidence and vitality to many men.
In usa, genuine products can be obtained only by prescription at a clinic or individual import through overseas mail order, and generic Cialis has not yet been approved, but generic drugs will be available in the future, so we hope to see more. It will be easier for you to use.
ED is neither an embarrassing illness nor a rare illness.
If you do n’t worry and talk to your doctor and get along well with Cialis, an ED treatment , you should be able to lead a comfortable life.
If you have any questions, please contact the clinic first.
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